Scientific Associate, Pre-clinical Genome Editing facility (12 months Fixed Term)
Fixed Term: 12 months
At the CRUK Cambridge Institute, we perform world leading science which focuses on positively impacting cancer patients' lives. In the Pre-Clinical Genome Editing team, our mission is to exploit technology to enable meaningful advances in understanding and treating cancer. We exploit and adapt cutting edge technologies to enable researchers to gain novel biological insight.
As a Scientific Associate, you will join the highly specialised Pre-Clinical Genome Editing team and apply your expertise to the genetic manipulation of complex, patient-relevant model systems. Our team has a wealth of expertise in CRISPR technology, its innovation and its application both in vitro and in vivo. You will complement our capability to both innovate the technology and to edit complex cellular systems. As a technology expert, you will work collaboratively with researchers to bring technological solutions to important biological questions.
Key Responsibilities:
You will complement our Genome Editing capability by:
- Working collaboratively with research groups, and other core facilities, to deliver high impact functional genomics-based projects
- Applying your expertise in advanced CRISPR technologies (eg PRIME editing) in the in vitro and in vivo setting
- Bridging project phases between in vitro CRISPR engineering and in vivo efficacy testing, ensuring continuity across systems and teams
- Contributing to novel technology adoption
Minimum Requirements:
- A Masters working on advanced CRISPR technologies
- Clear evidence of driving research projects autonomously ¿ both in vitro and in vivo
- Expertise in PRIME editing and other advanced CRISPR technologies
- Prior experience working with murine models, particular GEMMs
- Literate with CRISPResso2, PRISM, SnapGene software
- Robust molecular biology expertise (primary cell culture, electroporation, plasmid design, cloning, lentivector expertise, western blotting)
- Proactive, adaptable and enthusiastic about learning new concepts and technologies
- Excellent and effective communication skills are essential to this role.
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Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date: 18th July 2025
Interview date: to be confirmed
Please quote reference SW46532 on your application and in any correspondence about this vacancy.
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