Research Associate (Hendrich Lab) (Fixed Term)
A postdoctoral Research Associate position is currently available for an individual to work in the laboratory of Dr. Brian Hendrich within the Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/hendrich).
The Hendrich Lab studies how chromatin remodelling proteins are used by cells to alter gene expression patterns during cell fate decisions. We focus on how chromatin remodellers and extracellular signalling pathways coordinate to alter enhancer chromatin as mouse and human pluripotent stem cells undergo lineage commitment.
The successful candidate will undertake a project focused on determining how a chromatin remodelling complex controls expression of short interspersed nuclear elements (SINEs) in human pluripotent cells and orchestrates their use as enhancers during neural crest development. A good understanding of enhancer and chromatin biology is essential, and the ability to analyse next generation sequencing datasets using R-based programming would be advantageous.
The successful candidate will have a PhD, experience in mammalian stem cell culture and a strong grasp of molecular and biochemical lab techniques. The candidate will have a keen interest in the control of cell fate decisions and a good understanding of chromatin-based control of gene expression at both the 2D (DNA and chromatin) and 3D (nuclear organisation) levels. These will be supported by a proven track record in scientific publications. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have good presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers including supervising and training junior colleagues.
The Wellcome - MRC Cambridge Stem Cell Institute (CSCI) is a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/
Informal enquiries should be directed to Dr Brian Hendrich (bdh24@cam.ac.uk)
Fixed-term: The funds for this post are available for 3 years in the first instance.
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Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is: 18th June 2023
The interview date for the role is: To be confirmed
Please quote reference PS36815 on your application and in any correspondence about this vacancy.
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