University of Cambridge

Job Opportunities

Jobs

Research Associate*/Research Assistant (Fixed Term)


We are looking for a Bioinformatician to work on the Polygenic Score (PGS) Catalog, a collaborative project between the Department of Public Health & Primary Care, EMBL European Bioinformatics Institute, and Health Data Research UK. Since 2019, the PGS Catalog (www.PGSCatalog.org) has been a leading, high-quality data repository for published polygenic scores for a wide range of diseases (e.g. CVD, breast cancer, diabetes) and traits collected through curation and data submitted by authors. The database contains the information necessary for both research and clinical uses of PGS (e.g. SNP information, sample/cohort information, score development details, benchmarking), and is co-developed with the NHGRI-EBI GWAS Catalog (www.ebi.ac.uk/gwas).

The post holder will work directly with our team of expert genetic epidemiologists, biocurators, and a software developer as well as our users and data submitters/authors to deliver the PGS Catalog, a resource with real scientific impact and a variety of clinical applications (data from the Catalog has already been used to return results in clinical trials). The role of the bioinformatician will be to contribute to ongoing PGS Catalog development, software, and data analysis in the following ways:

  • Developing and deploying open-source software tools that allow polygenic scores from both the Catalog and user-developed scores to be calculated by external users and benchmarking cohorts. Examples of our current work can be found on our github (https://github.com/PGScatalog). For example, reporting of polygenic scores in the context of genetic ancestry and applications to alternative genotype data formats (e.g. whole-genome sequencing data).
  • Working with a software developer and colleagues at EBI to integrate the data flows between the GWAS and PGS Catalogs. For example, variant representation and harmonization.
  • Collaborate with other researchers and cohorts, to benchmark polygenic score performance.

The position will be jointly supervised by Prof. Samuel Lambert (Assistant Professor of Health Data Science) and Prof. Michael Inouye (Professor of Systems Genomics and Population Health). Our groups have a strong commitment to open-science and creating widely used resources (www.PGSCatalog.org, www.OmicsPred.org) and software tools (https://github.com/PGScatalog/pgsc_calc).

The post will be located at the new Victor Phillip Dahdaleh Heart & Lunch Research Institute on the Cambridge Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB

This position is available full-time or part time (0.8FTE) immediately.

The funding is available for this position until 30 September 2025.

*Appointment at Research Associate level is dependent on having a PhD (or equivalent experience), including those who have submitted but not yet received their PhD. Where a PhD has yet to be, awarded appointment will initially be made at research assistant and amended to research associate when the PhD is awarded (PhD needs to be awarded within 6 months of the start date). If an individual has not submitted a PhD or is not working towards one they could be appointed as a Research Assistant if they have either a degree (and/or Master's) in a relevant area or equivalent experience.

We strongly value and encourage Equity, Diversity and Inclusion as well as a flexible working environment.

If you have any questions about this vacancy or the application process, please contact Samuel Lambert sl925@medschl.cam.ac.uk

Location of post: Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Victor Phillip Dahdaleh Heart and Lung Research Institute, Papworth Road, Cambridge CB2 0BB.

Closing date: 18 June 2023

Interview date: 26 June 2023

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RH36221 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online