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PhD Studentship: Error-corrected sequencing of carcinogenic nitrosamines in a human liver spheroid model


AstraZeneca-Funded Non-Clinical PhD Studentship

PhD Studentship: Error-corrected sequencing of carcinogenic nitrosamines in a human liver spheroid model

Applications are invited for a 3.5 year PhD studentship based within the MRC Toxicology Unit, University of Cambridge, with extended industry experience at AstraZeneca (Cambridge, UK). The student will be working on a collaborative project jointly supervised by Dr Sarah Aitken (MRC Toxicology Unit, University of Cambridge) and Dr Anne Ashford (Genetic Toxicology, AstraZeneca).

We are seeking a highly motivated individual to undertake a combined experimental/computational project on drug-induced genotoxicity using human models. This is a mixed wet/dry lab project combining human liver models and sequencing. The purpose of the studentship is to apply NGS approaches to (i) understand mechanisms of nitrosamine-induced mutagenesis and (ii) advance the scientific understanding of carcinogenic risks associated with the exposure to nitrosamine impurities.

This studentship offers a unique training opportunity for engagement with leading academic and industry partners to change the current perception of the carcinogenic risk associated with nitrosamine impurities in drug products. Rotating between laboratories at the University of Cambridge and AstraZeneca the student will gain experience in a breadth of experimental and analytical techniques, including: molecular biology, cell culture, drug assays, error-corrected DNA sequencing, and statistical data analyses.

Applicants should have or shortly expect to obtain a first or good upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject such as Biomedical Science. Strong analytical skills, in addition to creativity, curiosity, enthusiasm, and the ability to work in a team are essential. This studentship is open to UK citizens or overseas students who meet the UK residency requirements (home fees) or are able to augment the funds to cover the extra costs associated with international student fees. Full details of the University's entrance requirements are specified here: http://www.graduate.study.cam.ac.uk/application-process/entry-requirements

REFERENCES:

Application Process:

Information regarding the application process can be found at: PhD Programme ' MRC Toxicology Unit (cam.ac.uk) https://www.mrc-tox.cam.ac.uk/phd-programme

All formal applications will need to be made through the University Application Portal: PhD in Biological Science (MRC Toxicology Unit) ' Postgraduate Admissions (cam.ac.uk) https://www.postgraduate.study.cam.ac.uk/courses/directory/bltopdtox

Your online application must include:

  • A CV, including full details of all University course grades to date
  • Contact details for two academic or professional referees
  • A personal statement of interest

Funding:

Full funding covering Maintenance and the University Composition Fee (Home Fee rate) and is provided for the studentship, with effect from 1 October 2023.

Maintenance fee is £19,500 in year 1, £20,100 in year 2, £20,700 in year 3 and £21,350 in year 4.

You are strongly recommended to contact the project supervisor prior to submitting your formal application to find out more about the project and eligibility: Dr Sarah Aitken sa696@cam.ac.uk and Dr Anne Ashford anne.ashford@astrazeneca.com

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.