Applications are invited for a Research Associate to join the group of Dr Matt Hoare within the new Early Cancer Institute on the Cambridge Biomedical Campus. Our group is interested in why patients with chronic liver disease develop liver cancer. This is an exciting opportunity to join a CRUK-funded 5-year project, based on previous findings from the group (Brunner et al, Nature, 2019; Ng et al, Nature, 2021) and will further define how acquired somatic mutations impact on cell survival, liver cancer development and systemic metabolic dysfunction.
We are seeking to hire a motivated post-doctoral Research Associate with a background in cancer research and mouse work to join the team. The successful candidate will join a pioneering research project investigating functional mechanisms and downstream consequences of somatic mutagenesis in the liver and, in particular, two recurrently mutated genes in chronic liver disease. To deliver this project the successful candidate will use a variety of in vitro and in vivo techniques, particularly novel mouse models of these acquired hepatocyte mutations. The successful candidate will join a successful and collaborative group in a new institute focussed on cancer early detection. In this post you will have the opportunity to develop your career, through cutting-edge research, interactions with great collaborators in the UK, Europe and the US and be placed on one of the largest biomedicine clusters in the UK.
Applicants should hold a PhD in cancer, metabolism or liver biology, or be close to the completion of their degree. Candidates that have a strong background any of the following three broad areas of expertise are encouraged to apply: (1) mouse models of cancer or liver disorders; (2) organoid derivation, culture and manipulation, or (3) single-cell multi-omics and epigenomics. Prospective candidates are encouraged to contact Dr Hoare (email@example.com) directly when considering an application to discuss the project in greater detail.
Fixed-term: The funds for this post are available for 5 years in the first instance.
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Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RD33224 on your application and in any correspondence about this vacancy.
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