The University of Cambridge wishes to appoint a Postdoctoral Research Associate to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit.
The post holder will work within a programme focused on mitochondrial transport proteins. Transport processes are crucial for the functioning of mammalian mitochondria and cells. Mutations in transport proteins cause a wide range of metabolic, neuromuscular and developmental diseases.
This program, funded by the Citrin Foundation (https://citrinfoundation.org), focuses on citrin deficiency, a phenotypically complex metabolic disease caused by mutations in the mitochondrial aspartate/glutamate carrier, also called citrin. Citrin deficiency is more prevalent in Asia but it is pan-ethnic and an increasing number of patients are being diagnosed across the globe. The goal is to understand the metabolic, bioenergetic and morphological consequences of citrin deficiency by studying the involvement of citrin in cellular processes in healthy and diseased states. The project involves collaborations between different experts on mitochondrial biology within the University of Cambridge and internationally. The post-holder will participate in every stage of the process, including establishing new cell models of citrin deficiency, reporting research advances to the Foundation, interacting with collaborators and preparing manuscripts.
Candidates will have a PhD in Cell Biology, or related discipline, and a track record of related research achievements. Extensive experience in metabolomics and microscopy techniques are required while prior experience in mitochondrial metabolism, bioenergetics, calcium signalling and cell stress responses are highly desirable. The post holder will be collaborating closely with other members of the Kunji group as well as with other collaborating groups. Several training opportunities on different aspects of mitochondrial biology will be provided.
The MRC Mitochondrial Biology Unit is a world-renowned centre for mitochondrial research. Additional information can be found at www.mrc-mbu.cam.ac.uk. Fixed-term: The funds for this post are available for 3 years in the first instance.
Fixed-term: The funds for this post are available until 28 February 2025 in the first instance.
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Closing Date: 16 October 2022
Interview Date: TBC
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.
Please quote reference SM33206 on your application and in any correspondence about this vacancy.
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