The Massie and Mair labs are seeking to recruit two talented and motivated Research Associates to join an exciting project exploring the use of novel epigenomic methods for improving cell free DNA (cfDNA) sensitivity and specificity in the early detection of cancer. This project aims to compare multiple novel epigenomic methods utilising a broad library of clinical and pre-clinical samples. A core objective of the project is to compare multiple epigenomic wet and dry lab techniques in order to take the best performing forward for further investigation. The successful applicants will work closely together but also within the wider Massie/Mair labs and their respective research environments (Early Detection Institute/CRUK Cambridge Institute). The project will initially focus on the use of targeted enzymatic conversion and nanopore sequencing methods. One post will be based at CRUK Cambridge Institute and the second at the Early Detection Institute both on the Cambridge Biomedical Campus.
The Massie lab has extensive experience in the application of epigenomic techniques to the field of cfDNA.
The Mair lab are using genomic and metabolic analysis to explore the cancer microenvironment. They have recently published on the use of epigenomic and targeted techniques for analysis of cfDNA in glioblastoma. They have access to a large array of primary human brain tumour and biofluid samples.
We are looking to recruit creative, enthusiastic and highly competent individuals with experience in cfDNA and epigenomics. Experience in the use of nanopore sequencing will be beneficial for one of the posts. It is expected that candidates will have wet and dry lab experience and be able to design/carry out experiments independently.
Applicants should have a PhD in a relevant discipline.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Closing Date: 5th June 2022.
Interview Date: TBC.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award.
Please quote reference SW31253 on your application and in any correspondence about this vacancy.
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