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Senior Scientific Associate - Systems Cancer Pathology (Ali Group) (Fixed Term)


We are recruiting a motivated Senior Scientific Associate to support and drive ongoing research in the Systems Cancer Pathology Group at CRUK, Cambridge Institute - https://www.cruk.cam.ac.uk/research-groups/Ali-group. The Ali lab investigates how the intersection between genetic clonal diversity, cell phenotype, and the tumour microenvironment drives disease progression. We use single-cell proteomic technologies (imaging mass cytometry in tissues) in combination with high resolution genomic data and quantitative analysis to understand tumours as complex, dynamic heterocellular ecosystems.

The successful candidate will be responsible for lab management, running and supervising experiments that involve an array of in-situ techniques including standard histochemical stains, microscopy, multiplexed immunofluorescence, in-situ hybridisation as well as imaging mass cytometry. You will work closely with computational biologists and core facilities to generate and analyse these high dimensional and interconnected datasets. You will also work closely with the group leader in managing the group, supporting funding applications and long-term planning.

It is possible that this role will develop into a long-term position with the lab. You will have the opportunity to work under your own initiative and apply problem solving skills. Experience in cancer biology is highly desirable, and ideally also previous experience with cancer histopathology and microscopy. Experience with generating single-cell data, CyTOF or imaging mass cytometry is desirable. You must be organised, meticulous and have a keen interest in developing computational data analysis skills.

Candidates are expected to be highly collaborative, good communicators, creative thinkers, able to find solutions to problems, to work effectively as part of a team and to contribute intellectually to projects developed in the laboratory. As a senior member of a newly established lab, it will be critical that you engender a positive, constructive, safe, and supportive culture within the group.

Our publications

Ali, H. R. et al. Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer. Nature Cancer 1, 163-175, doi:10.1038/s43018-020-0026-6 (2020).

Danenberg, E. et al. Breast tumor microenvironment structures are associated with genomic features and clinical outcome. Nature genetics, doi:10.1038/s41588-022-01041-y (2022).

Fixed-term: The funds for this post are available 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. This appointment also requires a Research Passport application.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 9th June 2022.

Interview Date: TBC.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW31241 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online