The Halim lab (https://www.cruk.cam.ac.uk/research-groups/halim-group) is actively recruiting highly talented and motivated scientists to join a vibrant and collaborative tumour immunology group within the University of Cambridge, CRUK Cambridge Institute. We are interested in understanding the role of innate lymphoid cells in regulating the immune response to cancer. Our long-term goal is to pharmacologically modulate the function of innate lymphoid cells with an aim to polarize the local immune environment towards an anti-cancer phenotype.
The postdoctoral researcher will benefit from collaborating directly on several mature projects, which we aim to submit for publication during this period. Additionally, there are opportunities for independently working on emerging projects in the lab.
As a postdoctoral researcher in the group, you will drive research projects that utilize novel in vivo and in vitro models to assess the function of immune cells in cancer, as well as study signalling pathways and downstream mechanisms using cutting edge genomic and proteomics approaches. You will join a collaborative and highly motivated team of researchers in a top ranked university and research institute. Our group is further supported by world-leading core facilities (https://www.cruk.cam.ac.uk/core-facilities) which researchers are encouraged to utilize to their fullest potential.
Candidates should be proficient in most of these:
- Mouse experimental procedures (existing UK PIL highly valued), tissue processing, isolation and phenotyping/manipulation of cells using:
- Advanced flow cytometry (i.e. high-parameter panel design, troubleshooting, data analysis)
- Immunological assays, IF microscopy, and cell culture
- Molecular biological techniques (i.e. cloning, viral vector design/production, genome editing strategies)
Candidate should have experience and/or a strong understanding in:
- Bioinformatic analysis (i.e. Experimental design of bulk or single cell transcriptomic experiments, generation of high quality datasets, independent or collaborative analysis of data)
- Tumour biology/immunology (i.e. experience with mouse tumour models, or human patient material)
The following additional skills are highly valued:
- High-parameter IF or mass-spec imaging, spatial transcriptomics
- Immunometabolic experience (i.e. metabolomic profiling, Seahorse analysis)
- Ideally you have demonstrated creative and independent work in your area of expertise.
Applicants who wish to be considered must display the ability to undertake project management, method development, data collection and analysis. You must have excellent communication and organizational skills, the ability to develop innovative experimental approaches to answer research questions, and thrive both in independent research and while working collaboratively as part of a team.
The successful candidate must have (or be about to receive) a PhD in immunology.
About Cancer Research UK, Cambridge Institute Europe's top cancer charity, Cancer Research UK, has teamed with the University of Cambridge to create the world class Cambridge Institute (CI) situated on the Addenbrooke's Biomedical Campus in Cambridge. The Halim lab has several ongoing clinical collaborations with Papworth and Addenbrooke's hospitals.
The Institute's research ranges from basic cancer biology through translational research to clinical application. The Institute currently houses over 350 researchers and contains new state-of-the-art research facilities. (http://www.cruk.cam.ac.uk/).
Temporary cover: This post is fixed-term for 18 months or the return of the post holder, whichever is the earlier.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Closing Date: 28th October 2021.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.
Please quote reference SW28376 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.