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Research Associate (Fixed Term)


The Physiology of Mutagenesis group led by Dr Serena Nik Zainal is based on the Cambridge Biomedical Research Campus as part of the MRC Cancer Unit and the Academic Department of Medical Genetics: https://www.mrc-cu.cam.ac.uk/research/serenanikzainal . We are seeking a capable data analyst/bioinformatician to join our team at an exciting time in the area of whole cancer genomics and mutagenesis.

Beyond the usual driver mutations that are sought in cancer genomics, detailed downstream analyses of all mutations present in cancers reveal mutational signatures that are the final outcome of combinations of DNA damage and DNA repair processes. Our team was involved in the initial conception of the field and latterly have pioneered experimental validation and development of novel clinical tools.

In the Physiology of Mutagenesis group, you will explore the aetiologies of mutational signatures, the mechanisms by which they arise and are embedded in the genome and develop new tools for clinical application. The role will involve data exploration of large cancer datasets and developing, testing and improving current algorithms for patient classification.

The post-holder shall have a PhD in genomics/computational biology/cancer biology and have an analytical track record preferably in genomics. Experience of NGS data processing is essential, with experience in whole genome sequencing data analysis being desirable. The post-holder shall have a high intensity period of pushing already-developed models to completion and be aiming for applying for post-doctoral fellowships or other senior bioinformatic positions. The post-holder shall have a strong track record of self-motivated scientific pursuit and be familiar with working in a high-performance compute environment, with an understanding of the sensitivities of working with clinical data. Experience of mutational signatures is desirable.

Fixed-term: The funds for this post are available until 31 October 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 19th September 2021

Interviews are expected to take place week commencing 27th September 2021.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,046) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference SK27852 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online