Investigating Alpha1-antitrypsin phase transition in the endoplasmic reticulum
We are seeking a post-doctoral research associate to join the Marciniak lab in CIMR to study the role of protein phase transitions in alpha1-antitrypsin deficiency. The Alpha1-Foundation-funded post is at research associate (post-doc) level and so a PhD in a relevant discipline and expertise in mammalian cell culture are essential. Experience in proteomics, flow cytometry, confocal microscopy or stem cells would be advantageous but not essential as training can be provided. The Marciniak lab combines cell biology, biochemistry, and translational medicine to understand the role of proteotoxicity in human disease (https://www.cimr.cam.ac.uk/staff/professor-stefan-marciniak). The successful applicant will use a variety of cutting-edge microscopy and proteomics techniques to understand the effects of protein phase transitions on function of the endoplasmic reticulum of iPSC-derived hepatocytes.
Recent relevant papers include
Ordonez A, Harding HP, Marciniak SJ, Ron D (2021). Cargo receptor-assisted endoplasmic reticulum export of pathogenic alpha1-antitrypsin polymers. Cell Reports doi: 10.1016/j.celrep.2021.10914 Chambers JE, Kubankova M, Huber, R, López-Duart I, Avezov E, Bond P., Marciniak SJ, Kuimova, M (2018) An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. ACS Nano 12:4398-4407. *Joint senior Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E. (2018). Single particle trajectories reveal active endoplasmic reticulum luminal flow. Nat Cell Biol 20:1118-1125 doi: 10.1038/s41556-018-0192-2.
Fixed-term: The funds for this post are available for 2 years in the first instance.
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Please quote reference SC27376 on your application and in any correspondence about this vacancy.
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