We are seeking to appoint a Research Associate to develop novel tools to target cellular senescence in cancer. The Research Associate will be based in the laboratory of Dr Daniel Munoz-Espin, Group Leader in the Department of Oncology at the University of Cambridge. This new post funded by a Cancer Research UK (CRUK) Programme Foundation Award is available from 1st July 2020.
One of the main goals of the Dr Munoz-Espin's research programme is the understanding of the mechanisms and processes that contribute to cancer progression and relapse, which remains a formidable challenge in oncology, and how to use this knowledge for the development of more efficient therapeutic strategies in precision medicine. We are looking for ambitious and highly motivated researchers to develop and validate novel senotherapies (aimed at eradicating senescent cells) with a particular focus on lung tumours. Candidates must have a PhD in the biological or biomedical sciences, and relevant experience working in cancer biology and animal models (essential). Skills in the development of organoids (tumoroids) and/or patient-derived tumour xenografts (PDTXs) is desirable. International experience and/or interconnections with the research industry would be desirable.
The successful applicant will have active access to cellular cancer models, genetically-engineered animal models of lung cancer and inducible ablation of cellular senescence, and also to primary cells from human tissue samples in collaboration with the Royal Papworth Hospital Research Tissue Bank (Cambridge). This work will be done in close collaboration with a competitive network of world-leading scientists, including consultant lung oncologists (Dr Robert Rintoul and Dr Gary Doherty at Papworth Hospital and Cambridge University Hospitals, respectively), experts in cellular senescence (Prof Manuel Serrano at IRB, Barcelona; and Prof Masashi Narita at Cambridge Cancer Institute), chemists and engineers (Prof Ramon Martinez-Manez at CIBER-BBN, Madrid; and Dr Ljiljana Fruk at Cambridge Department of Chemical Engineering and Biotechnology) and pharmaceutical partners (Senolytics Therapeutics SL). These studies will enable us to identify new therapeutic targets and to further prioritise novel pharmacologically-active drugs and delivery systems for tumour eradication. Beyond the preclinical proof-of-principle of the therapeutic activity of the most promising senotherapies the ultimate goal is the translation of our novel tools into early-phase clinical trials, and our experimental designs are optimised to facilitate such transition.
The laboratory of Dr Munoz-Espin (https://www.munoz-espinlab.com) is part of the Early Detection Programme of the Cancer Research UK Cambridge Centre, (http://www.earlydetectioncambridge.org.uk/), which is core funded by Cancer Research UK (http://www.cancerresearchuk.org/). Due to the internationally-renowned research institutions at the Cambridge Biomedical Research Campus (including the CRUK Cambridge Institute or the WT/MRC Cambridge Stem Cell Institute), the connections with Addenbrooke's and Papworth's hospitals, an increase in the number of biotechnology companies (such as AstraZeneca or Abcam), and the academic excellence of the University, Cambridge has become a worldwide recognised core for cancer research. Our location affords our members ready access to state-of-the-art research equipment and clinical facilities, cancer animal models, human tissue samples, and the opportunity to forge collaborations with world-class laboratory scientists and clinicians.
Informal enquiries are welcomed, and should be directed to Dr Munoz-Espin at firstname.lastname@example.org.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
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Closing date: 30th April 2020
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RD22541 on your application and in any correspondence about this vacancy.
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