Applications are invited for a Postdoctoral Research Associate position in the University of Cambridge, Department of Pharmacology, central Cambridge, working in the laboratory of Dr Graham Ladds. The lab uses multidisciplinary approaches to investigate G protein-couped receptor (GPCR) signalling and enjoys collaborations with both academia and industry. Webpage (https://www.phar.cam.ac.uk/research/Ladds) and twitter (@GPCR_Ladds). This project has arisen through a direct collaboration with Takeda Pharmaceuticals. The successful candidates should have (or be close to completing) a PhD in one of the following: Pharmacology, Biochemistry, Medicine or a related field. The project focusses upon GPCR pharmacology so experience in the used of mammalian tissue culture and BRET-based assays for GPCR research would be an advantage. The appointee will be enthusiastic, methodical, work effectively as part of a team, be able to perform and analyse experiments with appropriate supervision, willing to engage with the research literature, and able to write regular research reports. Experience of using GraphPad Prism is desired but not essential.
Funds are available for a fixed term of 30 months, after probationary review and is available immediately. The salary range for Research Associate is £32,816-£40,322.
Key duties will be to design, perform and analyse how the key regulatory proteins receptor activity modifying proteins (RAMPs) contribute to the gastric inhibitory polypeptide (GIP) receptor pharmacology. We will be studying GIPR agonist bias and cellular trafficking. We are keen to explore new signalling pathways modulate by GIPR and to determine how RAMPs influence these responses. Training in these techniques will be provided. This work builds upon ongoing projects in the Ladds-GPCR lab. More details are available on request.
Fixed-term: The funds for this post are available for 30 months in the first instance.
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