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Research Assistant/Associate (Fixed Term) - Design of MOFs for Targeted Delivery for Hard-to-Treat Cancers


The Adsorption and Advanced Materials Laboratory, headed by Dr David Fairen-Jimenez (http://people.ds.cam.ac.uk/df334), is looking for an outstanding postdoctoral research assistant/associate for a project involving the use of metal-organic frameworks (MOFs) in drug delivery for hard-to-treat cancers, to start on Q4 2018. The project is funded by the £10M EPSRC IRC grant in Targeted Delivery for Hard-to-Treat Cancers. The mission of this project is to lead the development, manufacture and validation of novel targeted drug delivery technologies that enhance bioavailability in hard-to-treat tumours, coupled with a timely clinical translation.

In particular, this position focuses in the development of drug nanocarriers based on metal-organic frameworks (MOFs), one of the most exciting developments in recent porous materials science. The project aims to leverage recent advances in the design of these advanced hybrid materials to create novel, high capacity delivery vehicles with targeting capabilities. We will advance their capacity to encapsulate difficult, hydrophobic drugs as well as macromolecules such as siRNAs, small mRNAs and inhibitor peptides. Here, we will: i) identify, design and develop optimal carrier materials with outstanding capacity; ii) modify the external surface chemistry of carriers to improve efficacy and targeting capabilities; iii) encapsulate and deliver hydrophobic drugs and siRNAs, mRNA and peptides.

The candidate must have a strong background in the area on drug delivery systems. This includes a PhD (or be close to completing a PhD) in chemistry, biology, materials science, or in a relevant science discipline. The candidate must be highly motivated and must have a strong academic record in terms of publications. The ability to work both as part of a team, and independently, coupled with excellent communication, organisational and problem solving skills are also required. The duties / responsibilities of this post include developing and driving research objectives; writing up work for presentations, publications and grant applications; collaborating with academic and industrial partners; co-supervision of PhD research projects and delivering seminars. It is expected that the candidate will contribute substantially to the future direction of the project. Fixed-term: The funds for this post are available for 24 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

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For further information, contact Dr David Fairen Jimenez via email - df334@cam.ac.uk

Please quote reference NQ24442 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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Further information

Apply online