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Bioinformatician (Fixed Term)


Applications are invited for a Bioinformatician to join Professor Patrick Chinnerys and Dr. Rita Horvaths groups, investigating mitochondrial disease and other inherited neurological disorders using computational and bioinformatics approaches.

The mitochondrial genomics group (Professor Patrick Chinnery and Dr. Rita Horvath) is seeking a talented Bioinformatician in computational biology/computer science/bioinformatics to join a team of clinical and laboratory scientists who are studying the role of genetic variation and differences in gene expression in rare inherited neurological diseases, including mitochondrial disorders. The post-holder will play a pivotal role coordinating and analysing new data as part of the 100,000 genomes project and the MRC funded International Centre for Genomic Medicine in Neuromuscular diseases. Both are landmark projects focussed on new disease gene discovery to underpin precision medicine.

Our laboratories study the mechanisms responsible for rare inherited neurological diseases with a particular emphasis on mitochondrial diseases. Our over-arching aim is to develop new treatments for rare inherited neurological diseases using a combination of genomic, cell biology, and informatic techniques on human DNA and tissue samples, and using cell and animal disease models. Understanding the molecular mechanism will reveal tissue specific targets and will provide rationale for developing novel therapies. Both teams published high-profile publications including Science, Nature Cell Biology (Wei et al. Science. 2019 May 24;364(6442); Floros et al. Nat Cell Biol. 2018 Aug;20(8):991).

The post holder will work closely with other bioinformaticians, laboratory and clinical scientists in the University, Wellcome Sanger Institute, and The European Bioinformatics Institute. In addition to collaboration with bioinformatics teams across the campus, the role holder will closely collaborate with groups within the Queen Square Centre for Neuromuscular Diseases, as part of the recently launched International Centre for Genomic Medicine in Neuromuscular Diseases across four continents

The post holder will have the opportunity to work on a range of experimental and publicly available datasets, including long and short-read whole genome sequencing (e.g. Illumina and Oxford Nanopore sequencing), whole exome sequencing, ultra-high depth DNA and RNA sequencing of the nuclear and mitochondrial genomes, single cell DNA-sequence and transcriptomic data, and epigenomic datasets. In addition to their own research, there will be opportunities for training and career development.

Post graduate education in computational biology at PhD level, ideally involving bioinformatics/ computational biology is essential.

For questions relating to the post, please contact Dr. Rita Horvath (rh732@medschl.cam.ac.uk) or Professor Patrick Chinnery: pfc25@medschl.cam.ac.uk

Fixed-term: The funds for this post are available until 31 May 2022 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing Date: 1st November 2020.

Please quote reference RR24266 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online