We are seeking a motivated post-doctoral researcher to develop statistical strategies which support genetic validation of therapeutic targets.
Recent availability of large-scale resources like UK Biobank, with genome-wide genetic data linked to thousands of diseases and related phenotypes now allow Phenome-wide association studies (PheWAS) and related analyses to be performed routinely. These assess the association of specific genetic instruments with a broad range of disease-related phenotypes. The goal of this two year post is to gain expertise in these techniques as they are currently used; to identify opportunities to improve the statistical rigour, and/or power (eg by exploiting additional information) of these methods; and to develop the methods needed to do. This is a fantastic opportunity not just to develop methods, but also to apply them to real problems in drug discovery and development.
The post holder will have a PhD in statistics, genetics, bioinformatics or another relevant subject. They will have expertise in high performance computing and data analysis language such as R, Python or Julia.
The post is based within the Wallace group in the Department of Medicine at the University of Cambridge (http://chr1swallace.github.io) and funded by GSK and Merck, giving an ideal environment to gain experience of scientific working in academia and industry. The post-holder will be predominantly based within the new Cambridge Institute of Therapeutic Immunology & Infectious Disease (https://www.citiid.cam.ac.uk) with close links to the MRC Biostatistics Unit (https://www.mrc-bsu.cam.ac.uk/), and it is envisaged the post-holder will also spend time in both industry locations, and will have regular face-to-face or virtual meetings with both industry partners.
This job is available immediately and can be started remotely whilst government and University advice encourages working from home.
Informal enquiries are welcome, and should be directed to Chris Wallace firstname.lastname@example.org
Fixed-term: The funds for this post are available for 2 years in the first instance.
We particularly welcome applications from candidates from a BAME background or other background for this vacancy as they are currently under-represented at this level in our Department.
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Closing Date: 25th October 2020
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RC24209 on your application and in any correspondence about this vacancy.
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