Applications are invited for a talented Bioinformatician/Biomathematician to join a team of clinical, laboratory and bioinformatics scientists in Professor Patrick Chinnery's Mitochondrial Genomics Group.
The role holder will harness existing tools and also develop novel methods to integrate and analyse diverse biological data sets. The over-arching aim will be to tackle research questions that are of fundamental importance for our understanding of mitochondrial biology in health and disease. Addressing these questions is now possible through the generation of high throughput transcriptome data generated using state of the art single cell approaches in collaboration with the Cambridge single cell unit. The over-arching aim of the project is to understand how mitochondria communicate with the cell nucleus during development and in disease, in order to understand the biology and develop new treatments for incurable disorders. Data sets will include whole genome, RNA Seq and Bisulfite sequencing enabling integrated multiomic analysis to address questions of fundamental biological importance including the role of oxidative metabolism during mammalian development and in late onset neurological disorders including Alzheimer's disease and Parkinson's disease.
The role holder will be closely integrated with a multi-disciplinary research group enabling the close interaction between the informatics team and both biologists and clinicians. In addition to their own world-leading research project there will be opportunities for training and career development.
The role is based in the MRC Mitochondrial Biology Unit within the Cambridge Institute for Medical Research on the Biomedical Campus. The over-arching aim of Professor Chinnery's research group is to understand the role of mitochondrial diseases with a view to developing new diagnostics and treatments for this patient group using a combination of genomic, cell biology and informatic techniques on human DNA and tissue samples and cell and animal disease models. The Chinnery group publishes between 40 and 50 papers a year including recent high-profile articles in Science & Nature Genetics. The role holder will join the Bioinformatics/Computational biology team at the Mitochondrial Biology Unit alongside 10 informaticians, providing close support and the opportunity to engage more widely within the research environment, including close collaboration with bioinformatic teams at Cambridge University, notably within the Stem Cell Institute, and also with collaborating groups at the European Bioinformatics Institute and The Wellcome Trust Sanger Institute.
The Head of Department may also from time to time require the role holder to perform other duties appropriate to the grade of the post.
Fixed-term: The funds for this post are available until 30 September 2023 in the first instance.
For questions relating to the post, please contact please contact Professor Chinnery on email@example.com
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Closing date: 26th April 2020
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RR22531 on your application and in any correspondence about this vacancy.
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