We are looking for a highly talented and motivated post-doctoral scientist to join the laboratory of Dr. Iva Tchasovnikarova at the Gurdon Institute, University of Cambridge.
The overarching goal of the Tchasovnikarova lab is to apply novel genetic approaches to answer outstanding questions in cancer epigenetics. Our research aims to (1) understand the molecular mechanisms utilised by chromatin regulators to exert their function in healthy human cells, and to (2) examine how these mechanisms are altered in cancer.
We take advantage of existing high-throughput genetic technologies, such as CRISPR/Cas9 genetic screens, to discover novel factors involved in chromatin pathways, which we then characterise using a combination of genetic and biochemical approaches. We are also particularly interested in developing novel genetic methods to study epigenetic pathways in human cells. Publications relevant to this position include:
Tchasovnikarova IA et al (2015) Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science, 348 (6242): 1481-5 Tchasovnikarova IA et al (2017) Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Nature Genetics, 49: 1035-1044 Further information can be found on the lab webpage, https://www.tchasovnikarova-lab.org
You should be passionate about cancer epigenetics, be willing to tackle difficult problems and be able to develop novel experimental approaches to answer outstanding questions in the field. While prior experience with mammalian cell culture, CRISPR genome editing, flow cytometry and next-generation sequencing would be advantageous, an eagerness to learn and to exploit and develop innovative methods is the critical requirement. You will play a key role in a small team so a friendly and collegial attitude is crucial, and you will be required to assist in the supervision of students.
You should have a PhD in a relevant subject, or be close to completion of your degree. This post will be available from Autumn 2020.
For further details or informal enquires please contact Iva via email (firstname.lastname@example.org).
Fixed-term: The funds for this post are available for 3 years in the first instance.
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