The ALBORADA Drug Discovery Institute (ADDI) at Cambridge, part of the University of Cambridge CIMR Division of Translational Medicine (http://cambridge-ddi.alzheimersresearchuk.org/), is seeking a Research Associate with knowledge of small molecule compound screening and assay development to join a large dynamic team of scientists. The ADDI forms part of the Alzheimer's Research UK funded Drug Discovery Alliance and prosecutes drug discovery projects from target to in vivo proof of concept and beyond for novel targets in the neurodegeneration therapeutic area.
The successful candidate will join our team responsible for assay development, working with state-of-the-art technology including acoustic liquid handling as well as developing and running both cellular and biochemical screens on libraries of up to 150K compounds. Reporting to the Screening Technologies Team Leader, the successful candidate will have experience in the development of automated, plate-based screening assays and will be expected to develop and execute a variety of biochemical and cell-based assays, aimed at screening for hits, determining structure-activity relationships and supporting the elucidation of the mechanism of action of active compounds. This is an exciting opportunity to join a cutting-edge drug discovery team focusing on the diseases that cause dementia and the candidate is expected to be highly organized, self-motivated, flexible, eager to identify and implement improvements to protocols and processes, and to be a strong team player.
The successful applicant will have (or be close to submission of) a PhD in a relevant subject or will be able to demostrate significant equivalent experience in an industrial, public sector or charitable drug discovery organisation. Up-to-date, hands-on experience in compound screening and statistical evaluation of data sets is required. It would also be advantageous to have experience of high content imaging, automation and/or phenotypic deconvolution. Proficiency in data analysis using relevant software (MS-Excel, Prism, Dotmatics, etc.), record-keeping skills and strong communication skills are also expected. The position is available to start immediately.
Specific enquiries about the post may be addressed to Dr. James Duce (email@example.com).
Fixed-term: The funds for this post are available until 31 August 2021 in the first instance.
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The closing date is 30 September 2019, with the interview date TBC.
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