A postdoctoral Research Associate position is available at the new Cambridge Dementia Research Institute based at the Addenbrookes Campus as a part of a multidisciplinary project in the group of Professor David Klenerman FMedSCi FRS.
The applicant will use a custom built single molecule fluorescence microscope to image and characterise individual aggregates in neurones and glial cells derived from induced pluripotent stem cells of human subjects, the supernatant above these cells and in aggregates present in human samples such as serum and cerebrospinal fluid. The aim of the project is to determine the molecular processes that lead to the initiation and spreading of neurodegenerative diseases, with a particular focus on Alzheimer's disease, by charactering the heterogeneous and low concentration of protein aggregates that are formed during the onset and development of disease using a suite of ultra-sensitive biophysical methods developed in the Klenerman group, based on single molecule fluorescence imaging. The project exploits these novel imaging methods (see Angew.Chem.Int. (2017) 56, 7750, ChemBioChem (2018) 19, 2033, Nature Comm. (2019), 10,1541 and Acta Neuropathologica Communications (2019) 7,120) that can be used to detect and characterise unlabelled protein aggregates in cells and human biofluids. It is part of a larger multidisciplinary project to determine the molecular basis of the initiation and spreading of Alzheimer's disease based in the Cambridge Dementia Research Institute.
Applicants should have a PhD in single molecule fluorescence or microscopy and a biophysical background and interest in performing multi-disciplinary research in a team. This is an ideal opportunity for physically trained scientist to apply imaging methods to tackle a major biomedical problem.
For queries relating to your application or the application process, please contact email@example.com.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
The closing date for applications is Sunday 22nd August 2019 with interviews expected to take place week commencing 30th September.
Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager
Please quote reference ZE20360 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.