We have a postdoctoral position available in the group of Dr. Yorgo Modis in the Department of Medicine Molecular Immunity Unit at the University of Cambridge to study cellular mechanisms of viral gene sensing and silencing. This post is funded by the Wellcome Trust.
We seek a highly motivated research scientist to study some of our most important antiviral innate immune defense mechanisms using a combination of cryoEM, X-ray crystallography, biochemical assays and cell-based functional assays.
Candidates must have a PhD in the biological, biochemical or biomedical sciences, and relevant research experience in protein biochemistry and macromolecular structure determination. Candidates must have at least one first-author research article accepted for publication in a major peer-reviewed journal. Experience in large-scale protein expression and purification with eukaryotic expression systems; in cryoEM tomography; or in focused ion beam milling is desirable.
The overall goal of the Modis group's research is to understand at the molecular level how cells recognize viral nucleic acids and respond with the necessary sensitivity and specificity. Our key research questions are: How does the cell distinguish between viral and cellular RNA? How does viral RNA recognition generate an immune response? And how is integrated viral DNA recognized and silenced? We integrate deep mechanistic insights from structural studies with functional validation in the cellular context. Our work will allow us to identify new therapeutic strategies.
The Modis group is part of the Molecular Immunity Unit within the MRC Laboratory of Molecular Biology (MRC-LMB). We benefit from the truly outstanding scientific environment and infrastructure of the MRC-LMB and from close links with the infectious disease and immunology community in the Department of Medicine.
Fixed-term: The funds for this post are available for 1 years in the first instance.
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Closing date: 27th October 2019
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RC20316 on your application and in any correspondence about this vacancy.
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