We seek a postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on the chemistry, structure and function of nucleic acids with an emphasis on their role in mechanisms of cancer biology. The post will be based in Cancer Research UK's Cambridge Institute (CI) and involves close collaboration with our sister laboratory based in the University Chemistry Department.
We have a vacancy for a molecular biologist/biochemist to contribute to our programme to explore and understand genome function. One of our projects aims to elucidate non-canonical nucleic acid structures in the genome and transcriptome. We are especially interested in how four-stranded nucleic acid structures (G-quadruplexes) and their interacting proteins influence DNA and RNA function as well as their impact on genome stability and cancer cell evolution. We are also exploring how such structures may represent targets for synthetic lethality-based approaches to intervene in cancer. A second project area concerns the role of modified DNA bases in normal biology and in cancer.
We seek a candidate with proven expertise in cloning and molecular biology, protein expression and purification, and cell biology. The candidate should also have a capacity to apply initiative and creativity to solve biological problems. Strong communication skills and an ability to work effectively as part of a multi-disciplinary team are essential.
Candidates should have (or be about to receive) a PhD in a relevant discipline. See https://www.balasubramanian.co.uk for further information.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
The closing date for applications is Thursday 15th August 2019 with interviews taking place early September.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.
Please quote reference SW19767 on your application and in any correspondence about this vacancy.
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