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Research Associate (Single Cell RNA-Sequencing and Functional Genomics in Cardiovascular Biology) (Fixed Term)


We invite applicants for a post-doctoral Research Associate post to undertake a research project in the group of Dr Helle Jørgensen (www.med.cam.ac.uk/jorgensen/) at the University of Cambridge. The position is available for 2 years in the first instance and is funded by the BHF Centre for Regenerative Medicine and is a collaboration with Dr Mikhail Spivakov (Functional Gene Control Group at MRC LMS, Imperial College London, lms.mrc.ac.uk/research-group/functional-gene-control/).

We investigate the regulation of cell plasticity and heterogeneity in the vasculature. Our group has a particular focus on proliferative responses, which has direct implication for neovascularisation and cardiovascular disease. We previously demonstrated a selective response of very few smooth muscle cells using clonal lineage tracing in animal models (see Chappell et al, PMID: 27682618) and used single cell RNA-sequencing to identify variable expression of disease-related genes that we propose underlie the observed functional heterogeneity (Dobnikar/Taylor et al, PMID: 30385745).

We are now seeking an individual to join our team to identify the mechanisms regulating selective activation of cells, which could be harnessed for tissue regeneration. The project will involve generation and mining of genomic datasets (e.g. single cell RNA-seq, ATAC-seq and ChIP-seq), in vitro investigations and testing in animal models. The candidate should have a strong background in in functional genomics data analysis preferentially with single cell data sets in an experimental research setting.

Essential skills:

  • PhD degree in a relevant area (e.g. biological science or a numeric discipline with experience in experimental research)
  • Experience in functional genomics data analysis, ideally using single cell technologies
  • Conceptual understanding of gene regulation
  • Interest in cardiovascular biology
  • Proactive attitude and drive
  • Strong communication skills and the ability to work effectively as part of an interdisciplinary team
  • Attention to detail and ability to multi-task
  • Experience in writing scientific manuscripts
  • Experience presenting ideas and findings

Desirable skills:

  • Experience in molecular and cell biology
  • Experience with animal models or primary cell culture
  • Strong publication record
  • Knowledge of cardiovascular biology
  • UK Home Office Personal Licence

The position is available immediately. Informal enquiries should be directed to Dr Helle Jørgensen (tel. 44 (0)1223 762581, e-mail hfj22@cam.ac.uk).

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 17th July 2019

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference RC19601 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online