The malaria parasite Plasmodium has a complex lifecycle involving several highly unusual cell cycles. Rather than conventional binary fission, it grows via syncytial modes of replication, producing multinucleate syncytia prior to budding and cytokinesis. This presumably requires unusual, sophisticated regulators of DNA replication, DNA repair and cell-cycle checkpoints, yet these are very poorly understood. The current first-line antimalarial drug, artemisinin, can cause DNA damage and drug-resistant parasites have recently arisen. Their resistance apparently involves parasite 'dormancy' - possibly via a cell-cycle checkpoint. This project will investigate how Plasmodium responds to DNA damage and how this may be linked to artemisinin resistance.
Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission Full details of the projects and how to apply are available from the following link: http://www.path.cam.ac.uk/graduate/fully-funded-studentships The studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about your fee status can be found at the following website: http://www.graduate.study.cam.ac.uk/finance/fees/what-my-fee-status . Applications from ineligible candidates will not be considered. Fixed-term: The funds for this post are available for 3 years in the first instance.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
General queries regarding these positions should be directed to firstname.lastname@example.org or Izzy Starkey 01223 333872.
Please quote reference PK19597 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.