Repositioning G-quadruplex-binding agents as antimalarial drugs
A postdoctoral research position is available in the laboratory of Dr Catherine Merrick, investigating the molecular mechanisms by which G-quadruplex binding agents can kill malaria parasites and the feasibility of repositioning such agents as candidate antimalarial drugs. G-quadruplex nucleic acid structures in Plasmodium are a major focus of research in the Merrick lab and this project will build on the recent publication by Harris et al., AAC 2018: 'G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets.' The project will involve a range of cutting-edge techniques in molecular genetics, genomics and cell biology across several Plasmodium species.
Applicants should hold a PhD in parasitology, molecular biology or genomics, with skills in cell culture, molecular biology and genomics/bioinformatics. Specific experience of Plasmodium culture, Plasmodium molecular genetics and genomic/transcriptomic techniques is desirable. The appointee will benefit from excellent facilities, including recently-refurbished Category-3 containment laboratories, and diverse expertise at the Cambridge Pathology Department.
The post will be available from Sept 1st 2019 Closing date for applications: 31st May 2019 Interviews will be held in mid June 2019
For further information please contact: email@example.com https://www.path.cam.ac.uk/directory/catherine-merrick/
Limited funding: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
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