University of Cambridge

Job Opportunities


Research Associate (Fixed Term)

*Genetic and Biochemical Analysis of receptor regulation *

Applications are invited for an enthusiastic, motivated individual for a Wellcome Trust funded postdoctoral position in the group of Professor Paul Lehner at the Cambridge Institute of Medical Research on the Cambridge Biomedical Campus, University of Cambridge. You will join an exciting research programme using genetic and proteomic approaches to understand membrane trafficking and receptor regulation pathways. (Menzies SA, et al. The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. eLife. (2018) PMC6292692 & Burr ML et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature (2017) PMC5706633). This post will involve the use of cutting edge genetic, biochemical, proteomic and bioinformatic techniques to study receptor regulation. Candidates should have a PhD with experience and a strong background in membrane protein biogenesis and degradation pathways.

Our group has a major interest in host-viral interactions and membrane trafficking pathways and is particularly adept at using genome-wide CRISPR Cas9 genetic screens to analyse pathways of receptor regulation. The project will focus on molecular and genetic analysis of receptor regulation. The successful candidate should have first author papers in peer reviewed journals and experience of working with membrane proteins and be skilled in molecular, biochemical and immunological techniques. The work will be multi-disciplinary, combining recently-established genome engineering and genetic screening approaches in human cells with next-generation sequencing, bioinformatics, cell biology, molecular biology and biochemistry.

Applicants should have excellent organisational and communication skills, and work well as part of a team

Fixed-term: The funds for this position are available for 3 years in the first instance with an immediate start date.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

For further details or informal enquires please contact Paul Lehner via email ( .

Please quote reference SC18075 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online