Applications are invited for a three-year PhD studentship position funded by the Department of Pathology, starting from 1 October 2019.
All biological processes are controlled and executed by proteins, whose function is regulated in space and time by post-translational modification (PTMs). Reversible PTMs, such as phosphorylation, are essential for the proper activity of many signalling pathways and networks that control almost every cellular and developmental process. Unsurprisingly, de-regulation of phosphorylation signalling pathways has been associated with many human disease, including cancer. Cell division represents an ideal system to study phosphorylation because gene transcription is severely limited by the inaccessibility of DNA. The identity and function of mitotic kinases have been studied is some detail, but very little is known about their counteracting phosphatases. The aim of this project is to characterize the roles of PP1 phosphatases during mitosis using a multi-systems approach combining gene editing, quantitative proteomics and multi-dimensional high resolution microscopy.
Owing to funding restrictions, the studentship is not available to non-EU nationals. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the language requirements for admission.
All applications should be made online via the University's Applicant Portal.
Funding will cover the student's stipend at the current Research Council rate and University Fees. The studentship will be funded for three years in the first instance subject to eligibility* with the possibility of additional funding in the fourth year depending on circumstances. Closing date: 28 February 2019.
*The studentship is available to students who quality for Home/EU fees Fixed-term: The funds for this post are available for 3 years in the first instance.
Informal enquiries should be made to firstname.lastname@example.org or call 01223 333872
Please quote reference PK18050 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.