University of Cambridge

Job Opportunities


Research Assistant - Zebrafish Models of MSD

Applications are invited for a Research Assistant to work with Professor David C. Rubinsztein and Dr Angeleen Fleming on zebrafish models of Multiple Sulfatase Deficiency (MSD).

MSD is a rare inherited metabolic disorder caused by mutations in the SUMF1 gene which encodes an enzyme that post-translationally activates all cellular sulfatases in the Endoplasmic Reticulum (ER). We have developed a zebrafish model of MSD and are recruiting a research assistant to work on a drug library screening project to identify molecules which may limit or halt disease progression.

Applicants should have a biological sciences degree and past laboratory experience. Experience of using zebrafish as a model organism would be beneficial but is not essential. Experience in molecular biology, imaging and western blotting would be advantageous.

Funding is available for a full-time post to begin immediately with current funding until April 2020.

Recent publications: - Moreau K., Fleming A., Imarisio S., Lopez A., Mercer J.L., Jimenez-Sanchez M., Bento C.F., Puri C., Zavodszky E., Siddiqi F., Lavau C.P., Betton M., O'Kane C.J., Wechsler D.S., Rubinsztein D.C. (2014). PICALM modulates autophagy activity and tau accumulation. Nature Communications 22;5:4998. - Lopez A., Lee S.E., Wojta K., Ramos E.M., Klein E., Chen J., Boxer A.L., Gorno-Tempini M.L., Geschwind D.H., Schlotawa L., Ogryzko N.V., Bigio E.H., Rogalski E., Weintraub S., Mesulam M.M., Tauopathy Genetics Consortium, Fleming A., Coppola G., Miller B.L., Rubinsztein D.C. (2017). A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain. 140(4):1128-1146. - Lopez A., Fleming A., Rubinsztein D.C. (2018) Seeing is believing: methods to monitor vertebrate autophagy in vivo. Open Biol. Oct 24;8(10).

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

The full incremental salary range for the position is advertised in order to demonstrate the progression of the Grade. In the majority of case appointments will be made at the Grade minimum: only in very specific circumstances can a higher salary be offered.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries to Dr. Angeleen Fleming (

Please quote reference SE18048 on your application and in any correspondence about this vacancy.

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Further information

Apply online