We wish to recruit an enthusiastic postdoctoral scientist to join a highly interactive team investigating the role of PI3K in host resistance to infection. The project will involve both genetic and pharmacological methods designed to explore how the inhibition of PI3K can suppress certain immune response yet enhance others. Determining the balance of these effects will help design strategies to use PI3K inhibitors are immunomodulatory drugs. This work is of relevance both to the recent discovery of a primary immunodeficiency syndrome called Activated PI3K Syndrome (APDS), but possibly also more broadly to individuals who as susceptible to viral and bacterial infections.
The position will be held a newly refurbished lab on Tennis Court Road at the Department of Pathology in Cambridge. The successful applicant will join a dynamic team of about 10 Postdocs and students. The Department is well-resourced and full access to flow cytometry, imaging, sequencing and biological services facilities will be available.
The applicant should have a PhD or equivalent in a relevant biological science. Ideally, the candidate will have experience working with mouse models of immunisation and/or infection. Experience with flow cytometry as well as cytokine and antibody detection methods will also be advantageous, training will be provided as needed.
Further Reading (all freely available at: https://www.path.cam.ac.uk/directory/klaus-okkenhaug/ ):
PI3K hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner Stark AK, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, Sriskantharajah S, Bradley G, Richter AG, Banham-Hall E, Clatworthy MR, Nejentsev S, Hamblin JN, Hessel EM, Condliffe AM, Okkenhaug K. Nat Commun. 2018 9(1):3174. doi: 10.1038/s41467-018-05674-8
PI3K and primary immunodeficiencies Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. Nat Rev Immunol. 2016 16(11):702-714. doi: 10.1038/nri.2016.93.
Key responsibilities -Plan and execute experiments according to the aims of the project -Record and analyse data, maintain accurate electronic records or research data -Present data at lab meetings -Organise the purchase, storage and record of reagents needed for the research
Selection criteria: Essential -PhD or equivalent in a biological science -Ability to work with mice -Ability to work as part of a team
Desirable -Research experience evidenced by data published in peer-reviewed journal -Home office personal licence (PIL) -Experience with mouse models of immunisation and infection -Experience with Flow Cytometry -Experience with ELISA and other techniques for measuring antibodies and cytokines
Limited funding: The funds for this post are available until 31 December 2021 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
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Any enquiries relating to the application process please contact Jodi Smith - firstname.lastname@example.org
Please quote reference PK17970 on your application and in any correspondence about this vacancy.
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