Project title: Matrix metalloproteinases, critical mediators of visceral nociception in inflammatory bowel disease?
Supervisors: David Bulmer (Pharmacology)
Project description Abdominal pain has a profound effect on the quality of life experienced by patients with inflammatory bowel disease (IBD). As part of an initiative led by Crohn's and Colitis UK to understand and treat pain in IBD we are pleased to offer a 3 year PhD studentship based at the Department of Pharmacology, University of Cambridge. This PhD builds on a body of work from the lab of the principal investigator (Dr David Bulmer) that has utilised tissue from IBD patients to identify new drug targets for pain in IBD such as the voltage gated sodium channel NaV1.9 (Hockley et al, 2014 PAIN 155 (10): 1962-1975) and the matrix metalloproteinase, macrophage metalloelastase (MMP-12) (Tranter et al 2017 J Crohns Colitis. 11: S120). This studentship will utilise data from a whole transcriptome analysis of IBD tissue that has identified several putative mediators of visceral nociception in IBD tissue from the matrix metalloproteinase family (MMPs). To do this we will utilise ex vivo electrophysiological recording techniques and calcium imaging to study the effect of MMPs and other inflammatory mediators identified in tissue samples from IBD patients on visceral nociception.
Applicants must have or expect to obtain at least an upper 2nd class honours science degree (or equivalent). The appointee will be motivated, capable of developing his or her own ideas, and keen to interact effectively with other lab members. The studentship is for up to 3 years and will provide a stipend at the standard Research Council rate, research costs and tuition fees. Funding is available only for UK or EAA students who meet the UK residency requirements. but please see information here regarding EU fee status for entry 2019 and onwards: https://www.graduate.study.cam.ac.uk/finance/fees. Informal enquiries to Dr Bulmer firstname.lastname@example.org
Applications from agencies will not be considered. How to apply All applications will need to be made through the University Application Portal: https://www.graduate.study.cam.ac.uk/courses/directory/blphpdphc/apply for further information about the programme and to access the Applicant Portal. Please note that the course code for PhD applications to Pharmacology is BLPH22. Whilst making your online application please make clear that you are applying for; proposed supervisor Dr David Bulmer and title Matrix metalloproteinases, critical mediators of visceral nociception in inflammatory bowel disease.
Your online application will need to include:
* Two academic references
* CV/resume * Evidence of competence in English
If required - you can check using our tool * Statement of interest (no more than 300 words) * Application cost £60 (you have 3 applications)
Informal enquires about application process must be sent to email@example.com The deadline for submission is 22ndth Feb 2019, with interviews likely to take place from the 11th March 2019.
Please quote reference PL17840 on your application and in any correspondence about this vacancy.
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