Applications are invited for a Research Associate Post in the Professor Patrick Chinnery Group
The mitochondrial genomics group (Prof Patrick Chinnery) is seeking a talented research associate in computational biology to join a team of informaticians and laboratory scientists who are studying the role of somatic mutations and mitochondrial dysfunction in ageing and neurodegenerative diseases. Our recent work has shown that de novo mutations occur during early brain development affect both the nuclear and mitochondrial DNA (mtDNA). Understanding how these mutations begin and spread during and after development is likely to have major importance for ageing and neurodegenerative diseases. The post holder will lead computational and mathematical approaches aimed at advancing our understanding of these biological mechanisms, and particularly how they are influenced by, and contribute to an age-related decline in mitochondrial function.
The post holder will work closely with laboratory scientists on a range of experimental and publicly available datasets, including ultra-high depth DNA sequencing of the nuclear and mitochondrial genomes, single cell DNA-sequence and transcriptomic data, and epigenomic datasets.
The main tasks will be:
- Developing computational and mathematical models describing the onset and spread of new nuclear and mtDNA mutations during development and throughout life.
- Testing and refining the models with existing and novel data sets.
- Contributing to the design and interpretation of laboratory experiments
- Close working with experimental laboratory scientists, including our main external collaborator (Dr Nick Jones, Imperial College London)
- Presentation at workshops and conferences
- Writing scientific manuscripts describing key findings.
- The opportunity to train others.
The post will be based physically within the MBU housed in the Wellcome Trust/MRC Building on the Cambridge Biomedical Campus. The MRC Mitochondrial Biology Unit includes eight other research groups studying the fundamental biology of mitochondria, how this changes in disease, and how to harness this knowledge to develop treatments. The unit has state-of-the-art facilities available to group members.
The post holder will be educated to degree level in a scientific discipline with a strong mathematical background (e.g. pure or applied mathematics, physics, engineering, bioinformatics, computer science or computational biology) Post graduate education or significant or extensive experience in computational biology at PhD level, ideally involving the mitochondrial biology is essential.
For questions relating to the post, please contact please contact Professor Chinnery on email@example.com
Fixed-term: The funds for this post are available for 3 years in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for this vacancy is 26th September 2018.
Please quote reference RR16690 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.