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Research Assistant/Associate in Modelling Particle Aerosolization and Deagglomeration in Pharmaceutical Power Inhalers (Fixed Term)


Fixed-term: The funds for this post are available until 30 September 2020 in the first instance.

The Macromolecular Materials Laboratory is seeking a Research Assistant/Associate to work on the modelling of entrainment and aerosolization of dry pharmaceutical powders in inhaler devices. The subsequent breakup and deagglomeration of particles will also be studied, using a combination of computational fluid dynamics (CFD) and discrete element models (DEM). The work is funded by the INFORM 2020 - Molecules to Manufacture: Processing and Formulation Engineering of Inhalable Nanoaggregates and Microparticles grant from EPSRC led by the University of Hertfordshire.

The post will be concerned initially with the numerical modelling of powder entrainment from aerosolization rig geometries with non-interacting, uniform particles using Eulerian-Eulerian CFD simulation approaches. Following that, the development of phase coupling algorithms, including agglomeration, will be combined with DEM models of powder mixing to develop Eulerian-Lagrangian codes to model aerodynamics shear and deagglomeration forces on particles in specific inhaler geometries. This will involve working closely with experimentalists working on determination of powder microstructure and cohesive force distributions to validate and parameterisatize the simulations. The successful candidate should have prior experience of using either CFD or DEM codes to model flow of powder particles with sizes in the range of 1 to 100 micrometres, excellent programming skills in C/C++ or FORTRAN, and the ability to work independently. Practical experience of CFD-DEM coupling methods is also highly desirable. The candidate should hold, or expect to hold shortly after appointment, a PhD in the area of Physics, Chemistry, Chemical Engineering or Materials Science.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

More details about the duties of each post, including further particulars, are available from the Head of Macromolecular Materials Laboratory, Prof James Elliott (jae1001@cam.ac.uk).

Please quote reference LJ16005 on your application and in any correspondence about this vacancy.

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