A postdoctoral position is available in the group of Ben Luisi in the Department of Biochemistry of the University of Cambridge in Central Cambridge, to work on multi-component drug efflux pumps (Du et al. (2014) Nature; Wang et al. (2017) eLife; Fitzpatrick et al. (2017) Nature Microbiology). A multi-disciplinary approach involving biochemical, biophysical and cellular experiments will be used to elucidate the molecular mechanisms of bacterial efflux pumps. The ultimate goal of the project is to advance our mechanistic understanding, by means of biochemical reconstitution and structural characterisation using purified protein components.
The main duties of the post will be to prepare membrane protein assemblies and determine the three dimensional structures by cryo electron microscopy. Candidates will hold or about to be awarded a PhD in Biochemistry, Biophysics or Molecular Biology and must have a proven track record of research achievements. Previous experience in the analysis of multi-protein complexes and membrane interactions, as well as familiarity with biophysical techniques such as X-ray crystallography, electron microscopy and single-particle analysis would be an advantage. Applicants with computational experience in cryoEM are also welcome to apply. The position would also be suitable for candidates trained in cellular biology and with an interest in the study of molecular mechanisms in vivo.
Fixed-term: The funds for this post are available for 3 years in the first instance.
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