University of Cambridge

Job Opportunities


Principal Scientific Associate, Genomics

The CRUK Cambridge Institute Genomics Core ( is looking for a talented laboratory-based scientist who will take ownership for delivering results in genomics experiments and technique development projects; as well as providing managerial input to our sequencing and library preparation services. This is a senior post in our team and you'll have the opportunity to make a significant contribution to the science in our institute. The Cancer Research UK Cambridge Institute, a department of the University of Cambridge, is one of Europe's top cancer research institutes. We are situated on the Addenbrooke's Biomedical Campus, and are part of both the University of Cambridge School of Clinical Medicine, and the Cambridge Cancer Centre. Our focus is high-quality basic and translational cancer research and the Institute has an excellent track record in cancer genomics. The majority of data generated by the Genomics Core facility is next generation sequencing (NGS), and we support researchers at the Cambridge Institute, as well as many other University Institutes and Departments within a NGS collaboration.

You'll be joining us at an exciting time as we expand our sequencing capacity (we have recently acquired a NovaSeq) to encompass large scale genomics projects, and continue to develop our utilisation and innovation of sequencing technologies, library preparation methods, and single cell techniques, to serve genomic projects for CRUK CI and the wider University.

This role is a mix of service provision and management, technique / assay development and experimental design, as well as general laboratory management and procurement; this will ideally suit a candidate willing and adept at a multi-role position that responds to the changing requirement of the Genomics Core Facility. In the first instance, the role holder will take a lead in directly managing the changes to our sequencing service provision as we incorporate large scale sequencing projects.

About you

Educated to PhD level or equivalent in a relevant subject or with equivalent experience, you will have extensive hands on laboratory experience in molecular biology, NGS, and analysis methods; being able to support and develop these assays. You have excellent communication skills and can work closely on project design, interacting with staff at all levels as well as externally to other University Departments.

You can advise the Core Facility Manager (CFM) on the latest equipment, genomics applications and best lab working practices, and be capable of deputising as required for the CFM; you can lead on project prioritisation, managing and escalating troubleshooting issues, and responding to requests from senior Institute or collaboration staff.

This is a hands-on role and you will be involved in processing of genomics experiments, which is likely to involve modifying existing, or developing novel methods; you will use your analytical skills to evaluate projects and feed back into method/study design. Experience with single-cell genomics or other genomics technologies is highly desirable, as is the use of automation for high throughput library prep. You are highly organised with a flexible and cooperative approach to work, work well in a team and be able to lead and mentor others, as well as be self-motivated and function very well in an unsupervised role.

You keep up to date with advances in NGS and single-cell genomics, and can write and/or contribute to production of research papers as necessary and present at relevant scientific conferences and meetings.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The closing date is 22nd July 2018. Interviews are likely to be held in the week beginning 30th July, when you will be asked to present for 10-15 minutes on "Current and future NGS applications to serve a cancer research institute".

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW15948 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online