The Alzheimer's Research UK Cambridge Drug Discovery Institute (DDI), part of the University of Cambridge CIMR Division of Translational Medicine (http://cambridge-ddi.alzheimersresearchuk.org/), is seeking a biologist or biochemist with experience in autophagy and expertise in cellular and molecular biology techniques.
The Cambridge DDI is collaborating with Prof. David Rubinsztein to develop therapeutics in neurodegeneration that induce autophagy to clear misfolded proteins. The successful candidate will work closely with the Rubinsztein laboratory to develop and execute a range of experiments in neuronal models to identify and validate targets and molecules for their potential to upregulate autophagy. The successful candidate will be lab based, have obtained a PhD (or equivalent) with relevant biological experience and contribute scientific leadership in a range of drug discovery and target validation projects involving autophagy.
You will have experience in the manipulation and analysis of gene/protein function in mammalian cells, ideally neuronal models. This should include gene transfer/RNAi, analysis of protein-protein interactions, gene expression and gene functional analysis. Experience with imaging-based assays and/or drug discovery would be desirable.
Working with chemists and other biologists in a stimulating and collaborative environment, this opportunity provides both training and development. The successful candidate is expected to be organised, flexible and eager to implement improvements to protocols. Interpersonal and communication skills are also expected.
Specific enquiries about the post may be addressed to Head of Biology Dr. James Duce (firstname.lastname@example.org).
Fixed-term: The funds for this post are available until 31 August 2020 in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing Date: 28th July 2018
Interview Date: to be confirmed
Please quote reference SA15875 on your application and in any correspondence about this vacancy.
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