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Research Assistant - Molecular mechanisms of the toxicity of protein misfolded oligomers (Fixed Term)


Fixed-term: The funds for this post are available for 4 years in the first instance.

Applications are invited for a Research Assistant to work with Prof Michele Vendruscolo, Prof. Tuoma Knowles and Prof Christopher Dobson in the Centre for Misfolding Diseases in the Department of Chemistry at the University of Cambridge. The Centre is engaged in research into protein aggregation and its links to human diseases, in particular concerning the formation of conformational states competent for protein aggregation, the formation of protein oligomers, the formation of the mature fibrils and the molecular determinants of protein oligomer toxicity. One essential part of our research is the development of potential strategies to inhibit the deleterious biological effects of protein aggregation and its resulting toxicity.

The succesful candidate will assist in the study of the structure of protein misfolded oligomers and on the factors responsible for their toxicity. The oligomers will be used to investigate their ability to interact with cultured cells and model of cell membranes, such as liposomes, with the objective of characterising the molecular determinants of protein oligomer toxicity.

Applicants should have a background in chemistry, biochemistry, molecular biology, biotechnology, or related discipline. Prior experience in protein aggregation and its related toxicity is not required, but the candidate should have an interest in applying biophysical methods to complex biomolecular systems and enjoy working in a multi-disciplinary environment.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Please ensure that you upload your Curriculum Vitae (CV), and a covering letter in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application. 

For queries relating to your application or the application process, please contact Echo Williamson via email on jw825@cam.ac.uk

Please quote reference MA15783 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online