Two research positions are available to work within the group of Prof Maria Grazia Spillantini based at the Clifford Allbutt Building within the Department of Clinical Neurosciences at the University of Cambridge. The post-holders will join a group dedicated to understanding the mechanism of neurodegeneration linked to protein aggregation, particularly tau and alpha-synuclein.
This position is funded by the Cambridge Biomedical Research Centre and the project aims to investigate tau characteristics and toxicity in human neurons derived from induced pluripotent stem cells from patients with tauopathies.
Several techniques will be used by the post-holder such as human cell culture, molecular biology, immunocytochemistry, immunohistochemistry, protein chemistry and light and confocal microscopy of human cells and tissue. Other techniques will also be used including electron microscopy and dSTORM. Knowledge in these fields can be useful although training can be provided. Experience on neuronal cell biology, molecular biology, neurodegenerative diseases with tau aggregates will be an advantage.
This position is funded by the JPND project "LODE: Loss of neurotrophic factors in neurodegenerative Dementias: Back to the cross roads of proteins" an international consortium comprising 4 research institutions across Europe (Italy, Germany, Belgium) and the USA. It seeks to uncover the relevance of neurotrophic factors and exosomes alterations in the pathogenesis of Alzheimer's and Parkinson's diseases. The post-holder will be based in Cambridge and will be involved in close collaboration with the other centres to determine in both animal and cellular models of protein aggregation whether reduction of neurotrophic factor availability and transport can influence disease development. The contribution will be critical to the work of the consortium.
Several techniques will be used by the post-holder, including human and mouse cell cultures, immunohistochemistry, exosome and protein purification and light and confocal microscopy. Other techniques will also be used including electron microscopy. Experience in these fields can be useful although training can be provided. Experience on neurodegenerative diseases with protein aggregates and/or exosomes and neurotrophic factors will be an advantage.
The post-holder will be in close contact with the other consortium members during the course of the project both through web-based conferences and regular consortium meetings.
Fixed-term: The funds for this post are available for 3 years in the first instance.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application.
Please clearly state in your application which project you are applying for (Lode or BRC).
The closing date is 27 June 2018.
If you have any questions about this vacancy or the application process, please contact firstname.lastname@example.org.
Please quote reference ZE15732 on your application and in any correspondence about this vacancy.
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