Post-doctoral Research Associate: Single molecule and super-resolution imaging of chromatin structure in mouse ES cells
Applications are invited for a Post-doctoral Research Associate who will be based in the Department of Biochemistry, University of Cambridge to carry out single molecule super-resolution imaging of chromatin structure and its assembly. You will join an MRC- and Wellcome Trust-funded research project focusing on understanding how the NuRD complex assembles and functions in mouse embryonic stem cells (mESC's). The work is carried out in a close collaboration involving Prof Ernest Laue at the Department of Biochemistry, Dr Brian Hendrich at the Stem Cell Institute and Professor David Klenerman at the Department of Chemistry.
This exciting and multi-disciplinary project exploits super-resolution fluorescence microscopy and single nucleus Hi-C experiments to study nuclear architecture (see Stevens et al., Nature, 2017, 544, 59-64; Lando et al., Nature Protocols, 2018, 13, 1034-1061; Lando et al., Nucleus, 2018, 9, 190-201). The project involves using molecular and cell biological techniques to tag particular proteins with photo-activatable fluorophores, and the study of these proteins in both fixed and live cells at the single molecule level.
The post would suit candidates with a strong multi-disciplinary background in single cell imaging and/or super- resolution microscopy. The successful candidate should have a PhD (or be close to completion).
Fixed-term: The funds for this post are available for 3 years in the first instance.
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Please quote reference PH15688 on your application and in any correspondence about this vacancy.
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