A postdoctoral position is available to work on a Wellcome Trust funded project to investigate the molecular mechanisms of regulation of alternative pre-mRNA splicing in the group of Prof. Chris Smith (https://www.bioc.cam.ac.uk/research/uto/smithc).
The position will be based in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge. The project focuses on the mechanisms by which regulatory RNA binding proteins control splicing complex assembly at regulated splice sites, and builds upon our recent discovery of a master splicing regulator that acts in smooth muscle cells. It will involve a range of biochemical, molecular, proteomic, biophysical, structural and single-molecule techniques based in the PI's and collaborators labs. We need to recruit someone with expertise in structural biology (X-ray crystallography, Cryo-EM) and associated biophysical techniques to complement our established expertise in RNA molecular biology. Prior knowledge or experience of RNA splicing, RNA biology or nucleic acid-protein assemblies would be an advantage.
The successful candidate will work in a research team comprising further post-doctoral researchers and Ph.D. students. They will need to have the initiative to work independently and as part of a team. The research will involve interaction with collaborators groups so good communication and interpersonal skills are required. In addition to carrying out research they will be expected to present research findings, contribute to writing manuscripts and supervise students in the laboratory.
The successful candidate will have a PhD or has recently submitted for a PhD.
Fixed-term: The funds for this post are available for 5 years in the first instance.
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