University of Cambridge

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Research Associate in Molecular and Cellular Neurobiology of phase separating intrinsically disorder proteins in Neurodegenerative Diseases.

The successful candidate will join a world-leading, multidisciplinary research team located at the Cambridge Institute for Medical Research (CIMR). The team headed by Prof Peter St George-Hyslop works on the molecular/cellular biology, biochemistry and structural biology of proteins involved in normal neuronal function and in human neurodegenerative diseases

The long term goal of the program is to understand how phase separation regulates new protein synthesis in dendrites and axon terminals. The program also wishes to understand how mutations and/or post-translational modification of proteins alter these processes and injure neurons and glia.

The present project will principally focus on intrinsically disordered/natively unstructured proteins such as FUS, TDP43, and tau which we have recently shown undergo reversible phase transitions, a process which cause neurodegeneration when it becomes perverted (Neuron, 2015; Cell, 2018).

The person appointed should have a PhD and will have familiarity with standard molecular and cell biological techniques including high resolution and live cell imaging. A particular interest and expertise in the biochemistry, molecular biology, and cell biology of primary and iPSC-derived / induced neurons would be an asset

The successful candidate will join a highly interactive lab and will be expected to participate in open academic discussions, in the creation of new experiments, the analysis of emerging experimental data, and in the constructive criticism of draft manuscripts and grant applications. They will also be expected to present their data at informal internal presentations within CIMR, and at formal external scientific conferences.

Significant scope is provided to allow creative postdoctoral researchers to initiate independent lines of work some or all of which may ultimately form the basis for starting their own independent research laboratory.

The successful candidates will be expected to supervise the work of a technician collaborating with them on their project and may also supervise one or more graduate students in the laboratory.

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

If you have any questions about this vacancy please contact Prof Peter St George Hyslop, email .

Please quote reference SD15210 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information

Apply online