Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. We are looking for a highly motivated bioinformatics/computational biology post-doctoral associate to join our collaborative research team. We aim to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs.
The successful candidate will work alongside experimental scientists to formulate and test hypotheses that underpin a new approach to therapy for neuroblastoma, providing bioinformatic interpretation of genome-wide datasets, including ChIPseq, RNAseq and ATACseq generated by research scientists in the Philpott lab. The successful candidate will also integrate these with data from patient cohort datasets. Work includes data processing, statistical analysis, integration and visualization of disparate datasets, development of analysis workflows and training, data management, experimental design and hypothesis generation. The successful candidate will have the opportunity to work under their own initiative and apply their problem solving skills to troubleshoot challenging issues. There is potential for someone who is primarily bioinformatically-focussed to also take part in some experimental work if desired and time permitting. Applicants will have a PhD and sufficient experience of genome-wide analysis techniques to work independently and within a group.
Our group is embedded within the world-class infrastructure on the Cambridge Biomedical Campus, in the the Department of Oncology at the University of Cambridge (https://www.oncology.cam.ac.uk/research/) and will be moving to the newly constructed Wellcome-MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk) in autumn/winter 2018/19. We work closely with Dr Jason Carroll in the CRUK Cambridge Institute, Prof. Ben Simons in the Stem Cell Institute and other research groups nationally and internationally to advance research on developing new treatments for neuroblastoma.
The position is supported by a grant from Cancer Research UK and the funding supporting this position is available for three years in the first instance.
Please contact Professor Anna Philpott (firstname.lastname@example.org) with any informal enquiries.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is Monday 12th of August 2018 and interviews are yet to be confirmed.
Please quote reference RD15149 on your application and in any correspondence about this vacancy.
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