Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. The aim of the Philpott lab is to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs. We are looking a highly motivated post-doctoral scientist to join our collaborative research team.
Investigation of the genome-wide effects of post-translational regulation of key transcription factors in Neuroblastoma cancer cells:
You will use genome-wide techniques such as Chipseq/RNAseq/ATACseq to interrogate the transcriptional and epigenetic control of gene pathways regulating proliferation versus differentiation in neuroblastoma cells.
You will also investigate the use of drugs that target high level transcription of oncogenic proteins and epigenetic regulators to develop new methods of targeting neuroblastoma therapeutically.
The successful candidate will lead their own project while working closely with other group members and collaborators, using a variety of cell culture and genome-wide analysis techniques along with biochemical and molecular biology approaches. Good organisational skills and experience with tissue culture is a requirement for these posts. Previous experience of genome-wide analysis methods would be an advantage.
Our group is embedded within the world-class infrastructure on the Cambridge Biomedical Campus, in the Department of Oncology at the University of Cambridge (https://www.oncology.cam.ac.uk/research/) and will be moving to the newly constructed Wellcome-MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk) in autumn/winter 2018. We work closely with Dr Jason Carroll in the CRUK Cambridge Institute, Prof. Ben Simons in the Stem Cell Institute and other research groups nationally and internationally to advance research on developing new treatments for neuroblastoma.
The position is supported by a grant from Cancer Research UK and the funding supporting this position is available for three years in the first instance.
Please contact Professor Anna Philpott (firstname.lastname@example.org) with any informal enquiries.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check and a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is Sunday 12th of August 2018 and interviews are yet to be confirmed.
Please quote reference RD15133 on your application and in any correspondence about this vacancy.
The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.