University of Cambridge

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Research Associate - Modelling Cystic Fibrosis using Human Pluripotent Stem Cells (Fixed Term)

The Vallier laboratory is looking for a highly motivated individual to join our research team devoted to developing new therapies using human pluripotent stem cells. The objective of the laboratory is to uncover the basic mechanisms controlling differentiation of pluripotent cells into endoderm progenitors from which the pancreas, lung, gut and liver originate. For that we use human pluripotent stem cells (embryonic and induced) as an in vitro model of development. The overall objective is not only to acquire the knowledge necessary to control differentiation of pluripotent stem cells into specific endodermal organs but also to generate cell types for clinical studies of inherited disorders and for cell based therapy. Projects currently underway aim to generate functional pancreatic, liver, gut and lung cells not only for regenerative medicine but also for disease modelling and drug screening.

The objectives of the current project are (i) to establish a new method for differentiating human pluripotent stem cells into basal lung cells (ii) to improve CRIPSR/Cas9 technology to correct genomic mutation inducing Cystic Fibrosis (CF) and (iii) demonstrate that the resulting cells can be used for disease modelling and for cell based therapy in the context of CF. This project is funded by the UK Cystic Fibrosis Trust a none profit organisation established to cure and to control CF. This project is part of the of the Cystic Fibrosis innovation Hub leaded by Professor Andres Floto ( This program of research is related to our previous work on the production of liver and pancreatic cells from human pluripotent stem cells and recent technical developments on single cell profiling generated by our group.

Qualifications and experience: PhD or equivalent and strong background in human pluripotent stem cell culture experience and computational biology is absolutely required. Good organizational, analytical, and communication skills are essential.

Fixed-term: The funds for this post are available until 31 January 2020 in the first instance.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Closing date: 25th March 2018

Interview Date: w/c 2nd April 2018

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference RE14898 on your application and in any correspondence about this vacancy.

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Further information

Apply online