We are seeking a highly motivated PhD student with a strong academic background in natural sciences and an interest in biophysical methods to work with Prof. Sophie Jackson on the physical stability of therapeutic peptides. The 3-year project is funded by MedImmune Ltd (the biopharmaceutical subsidiary of AstraZeneca), and will focus on a study of the chemical and organic impurities arising during MEDI0382 Drug Substance (DS) and Drug Product (DP) manufacture under different process conditions, exploring the relationship between these impurities and the physical stability of the peptide. The aim will be to gain a better understanding of the mechanisms underlying gel and fibril formation and how this relates to the different processing conditions. We will aim to identify predictors of early fibril formation and physical instability in the formulated Drug Product, and to identify predictors of early fibril formation leading to physical instability in synthetic peptide formulations. The project will be interdisciplinary with emphasis on physical methods (such as mass spectrometry and solid-state NMR) to study peptide purity, structure and aggregation.
Applicants should have (or expect to obtain) the equivalent of a UK first class or upper second class honours degree (and preferably a Masters degree) in chemistry, biochemistry, physics, or other relevant discipline, and must have an interest in using physical methods to study biological systems. The studentship provides a maintenance grant and tuition fees at the UK/EU rate. Non-EU nationals can be considered only if they already have the means to fund the overseas fees differential.
Applications should emailed to Harriet Kerridge (firstname.lastname@example.org), and should include a CV, detailed academic transcripts, a cover letter highlighting what you can bring to the project, and the contact details for two academic referees. For informal enquiries please contact Prof. Sophie Jackson (email@example.com).
Please quote reference MA14643 on your application and in any correspondence about this vacancy.