Are you interested in using state of the art mass spectrometry techniques to develop new diagnostic markers for diseases and understand their underlying mechanisms? An exciting opportunity to work in the area of mass spectrometry based metabolomics has arisen with the creation of a Research Associate post to work in the Griffin group at the Department of Biochemistry. Using state of the art Mass Spectrometry and NMR spectroscopy, the group analyses a range of human and other biological tissues to obtain complex spectra which, through careful analysis can lead to better mechanistic understanding of disease as well as potentially important medical breakthroughs by developing novel biomarkers and measuring drug efficacy as part of precision and stratified medicine approaches. In particular the group has a strong focus on aspects of the metabolic syndrome and why the inappropriate accumulation of lipids can produce cellular and tissue dysfunction.
Working as part of a team, the post holder will primarily be responsible for developing methods using a triple quadrupole instrument for targeted analysis of small molecules and lipids, including the use of stable isotopes for flux analysis. In addition the post will also involve meeting with new users to describe the methods available, running both targeted and open profiling metabolomic and lipidomic workflows, processing the data and discussing the results with team members and collaborators. This role will involve a wide range of biological applications and analytical approaches and would suit someone with a degree of independence and the ability to problem solve. Experience of mass spectrometry is a must and use of triple quadrupoles for targeted workflows would be a benefit.
The candidate should have at least a PhD (or equivalent) in analytical chemistry, metabolomics, proteomics or another related field which makes use of mass spectrometry and/or chromatography separation. Practical experience of modern mass spectrometry techniques are essential for this post. Good team working skills will be essential as will excellent communication skills and ability to work to deadlines whilst maintaining a high level of accuracy.
Fixed-term: The funds for this post are available for 12 months in the first instance.
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Please quote reference PH14252 on your application and in any correspondence about this vacancy.
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