An MRC funded postdoctoral position is available in the laboratory of Dr Andras Lakatos at the University of Cambridge. The research group focuses on regulators of transcriptional networks and novel signalling pathways in astrocyte-neuron-synapse interactions. In specific, this exciting project is aimed at elucidating mechanisms underlying novel cell-communication pathways under physiological conditions, injury and in neurodegenerative diseases, such as Motor Neuron Disease (MND)/Amyotrophic Lateral Sclerosis (ALS).
The successful applicant will use cutting-edge technologies, including in vivo/ex vivo transgenic mouse and/or translational human disease models in combination with computational approaches to reveal astrocyte-mediated mechanisms driving degeneration or recovery of the neuronal network.
The candidate must have a PhD (or equivalent) in neurosciences or biological sciences with first author publication(s) and a strong background in mammalian cell culture techniques, cell and molecular biology. Experience in at least one of the following areas is desired: human stem cell biology, CRISPR/Cas9 genome editing, calcium imaging, analysis of RNA-sequencing and proteomic data, computational modelling and network analysis. We seek a candidate with strong organisational skills and aptitude for semi-independent and team work.
The John van Geest Centre for Brain Repair is one of the leading centres dedicated to regenerative neurosciences. This is a multidisciplinary institute within the Department of Clinical Neurosciences at Cambridge and is part of the Cambridge Neuroscience Network. The Lakatos laboratory also has collaborations in the MRC Laboratory of Molecular Biology (LMB), the Wellcome Trust-MRC Stem Cell Institute at Cambridge and the European Bioinformatics Institute (EBI). The appointee will join a vibrant and international research environment, which has a strong track record for empowering exceptional scientists and supporting the career development for postdocs and graduate students.
The post is a unique opportunity for a scientist in regenerative neurobiology, who will join a dynamic group of basic and clinician scientists and will interact with collaborating groups in the UK and USA to pursue fundamental and clinically relevant questions in neurosciences.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Key Publications: 1) Tyzack, G.E., Hall, C.E., Sibley, C.R., Cymes, T., Forostyak, S., Carlino, G., Meyer, I., Schiavo, G., Zhang, C-S., Gibbons, G.M., Newcombe, J., Patani, R, & Lakatos, A. A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models (2017). Nature communications 8:1164
2) Tyzack, E.G., Sitnikov, S., Barson, D., Lau, N., Adams-Carr, K., Kwok, J.C., Zhao, C., Franklin, R.J., Karadottir, R.T., Fawcett, J.W. & Lakatos, A. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression (2014). Nature communications 5:4294
If you have any questions about this vacancy or the application process, please contact Dr Andras Lakatos by email at the first instance (AL291@cam.ac.uk). For further information about the laboratory please visit: http://www.neuroscience.cam.ac.uk/directory/profile.php?lakand
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Closing date for applications is the 17th December 2017.
Please quote reference ZE14036 on your application and in any correspondence about this vacancy.
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