The Cancer Research UK Cambridge Institute (CRUK CI) is a department within the University of Cambridge, Clinical School and has the specific goal to harness the scientific strengths of Cambridge to solve problems encountered with the treatment, diagnosis and prevention of cancer.
Applications are now invited for a post-doctoral research associate position to take part in the IMAXT project, an incredibly ambitious and exciting endeavour launched by the Hannon laboratory at the Cancer Research UK Cambridge Institute, recipient of one of the CRUK "Grand Challenge" awards with £20 million funding over 6 years (http://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/grand-challenge-award/ and https://imaxt.cruk.cam.ac.uk ).
The IMAXT project aims to understand breast cancer from an evolutionary and ecological perspective at a level never before achieved. We aim to understand the interactions between tumour and host in a holistic manner but with the resolution to understand the behaviour and contributions of each individual cell. We wish to understand the genetic and phenotypic diversity of breast tumours and how these properties evolved during tumour development. Individual projects within the Grand Challenge group will concentrate on critical questions in breast cancer from the earliest stages of disease to the development of lethal metastases and will combine analyses of mouse models (both syngeneic and patient-derived) and clinically annotated human samples.
The team will combine cutting edge high-throughput imaging and measurement technologies like serial two-photon tomography, imaging mass cytometry, multiplexed fluorescence in-situ hybridization and in-situ sequencing to produce molecularly annotated 3D maps of biopsies and whole tumours, both in animal tumour models and on patient samples. The data will be represented as a computerized model using virtual reality, creating a completely new way for scientists and clinicians to look and work together on tumour data. The Hannon lab is collaborating with a group of international experts including cancer biologists, astronomers, imaging experts, chemists, mathematicians and software designers to push the boundaries of what can be done in the cancer biology.
As a postdoctoral associate working in the early phase of the project, the successful candidate will have a great opportunity to contribute to this momentous effort and leave a mark on the evolution of the field. The IMAXT group is looking for talented cell and molecular biologists with a good knowledge of advanced microscopy technologies and/or of bioinformatics to contribute to different areas of the project.
The successful candidate should have (or be about to receive) a PhD (or equivalent) in a relevant discipline. They should have a strong background in molecular biology and cell biology. Experience in microscopy, chemistry or bioinformatics is desirable. Candidates are expected to be communicators, independent thinkers, and have the ability to bring innovation to the field and problem solve. They should be able to collaborate effectively with people with different backgrounds to further the aims of this challenging project.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
The closing date for applications is Sunday 10th December 2017, with interviews yet to be confirmed.
Please quote reference SW13966 on your application and in any correspondence about this vacancy.
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