Ribosomes are central for protein synthesis in all cells. How are ribosomes assembled and how is the integrity of this process monitored? How does perturbation of this universal process in the fascinating and rapidly expanding group of diseases called ribosomopathies cause tissue specific defects, blood stem cell dysfunction and predisposition to cancer? We seek a highly motivated researcher to gain insight into the mechanisms driving ribosome assembly and elucidate how corruption of this process causes developmental defects and cancer predisposition.
The Warren lab based in the Cambridge Institute for Medical Research has a strong track record in elucidating the mechanisms of ribosome maturation corrupted in human disease using multidisciplinary approaches ranging across genetic analysis in animal models, biochemistry and structural studies, including the recent advances in single-particle cryo-electron microscopy (Warren AJ. Adv Biol Regul doi: 10.1016/j.jbior.2017.09.002; Weis et al. Nature Struct Biol 22: 914-19; Wong et al. Blood 118:4305-12; Barlow et al. Nat Med. 16: 59-66; Finch et al. Genes Dev 25: 917-929; Menne et al. Nature Genetics 39: 486-95).
The candidate will have a PhD in the biological, biochemical or biomedical sciences with relevant research experience in molecular biology and at least one first author primary research article in a major peer-reviewed journal. The successful applicant will work as part of a multidisciplinary team and will have the opportunity to gain expertise in structural, cell biological and biochemical techniques. Individuals with experience in mammalian cell culture, CRISPR/Cas or animal modelling are also encouraged to apply.
You will be joining a lab of international reputation working at the forefront of its field. Our work has substantial funding from Bloodwise and the Medical Research Council and a wide range of productive collaborations and associations. You will benefit from the expanding high level cryo-electron microscopy (Talos Artica/Titan Krios) and computing infrastructure at the University of Cambridge, access to the Diamond eBIC facility and the support and collaboration of highly skilled colleagues. This is an excellent opportunity for someone wishing to make an important contribution in an exciting and fast moving field.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Informal enquiries are welcomed and should be directed to Professor Warren at email@example.com .
Martin Dawes is responsible for the recruitment for this post and can be contacted at firstname.lastname@example.org.
Interviews are expected to be held in the week commencing 18 December 2017.
Please quote reference SB13957 on your application and in any correspondence about this vacancy.
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