The Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments.
Applications are invited for a postdoctoral position to explore how quiescent state is maintained and becomes activated in lung homeostasis and regeneration. The position, which is supported by an ERC Grant, will be hosted in the Cambridge Stem Cell Institute (CSCI) and is associated with Dr. Joo-Hyeon Lee's group.
The project aims at investigating (re)programming of lineage commitment during lung injury repair and regeneration. In order to advance our understanding in this field, we have created new lineage tracing models with selective cell modification. Drawing upon developments in mathematical modelling, advanced imaging and image-analysis, we will define the clonal dynamics of epithelial stem cells in adult lungs under different conditions: homeostasis, regeneration and/or inflammation. In addition to apply to genetic models, we also utilise co-culture system and single cell molecular analysis to dissect the cellular and molecular hierarchy of lineage commitment in various conditions.
Candidates should hold a PhD (or equivalent) in a relevant field. In particular they will have a background in molecular/cellular biology and genetics, knowledge in molecular cloning, lineage tracing, confocal imaging and image processing/analysis, experience in epithelial biology with murine genetic models, experience in primary cell culture, tissue clearing, fluorescence imaging, fluorescence activated cell analysis and cell sorting and a proven capacity to design, execute and correctly interpret their own experiments.
Candidates should be able to communicate effectively and be independent and collaborative.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Fixed-term: The funds for this post are available for 2 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.
To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing date for applications is the 1st November 2017, with interviews yet to be confirmed by the department.
Please quote reference PS13459 on your application and in any correspondence about this vacancy.
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