University of Cambridge

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CRUK Studentship - Winton

The Cancer Research UK Cambridge Institute, a department of the University of Cambridge hosts research ranging from basic cancer and computational biology through to translational research and clinical application. Postgraduate students play a pivotal role in the continuing success of our research programmes and the Institute provides an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future.

Dr Doug Winton (DW) is seeking a student to work on Defining stem cell territories in human colonic crypts.

Project details - The functional organization of stem cell replacement in the glandular epithelium of both mouse and human colon has recently been described. Analysis of the changing size distribution and accumulation of somatic clones with age has defined the activity of a small number of clonogenic stem cells within each gland or crypt. These compete with each other through sequential loss and replacement events until crypts become monoclonally converted, i.e. populated by the progeny of a single clone. However, the dynamics of the process is very different in mouse and human. In the former, monoclonal conversion takes weeks while in human it takes many years. The aim of the project is to describe the differences in stem cell behaviours between the two species that cause these different dynamics.

The position will be based at the CRUK Cambridge Institute but the successful applicant will spend periods of time at the lab of Dr Williams at University of East Anglia, Norwich, England.

Preferred skills/knowledge - Applicants should have an undergraduate degree in biological sciences, and substantial experience of working in laboratory environments where they have acquired research skills relating to molecular and cellular biology. In addition, skills in quantitative biology methods or computing language will be helpful.

Funding - This studentship is funded by Cancer Research UK and includes full funding for University and College fees and in addition, a stipend of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.

Eligibility - No nationality restrictions apply to this Cancer Research UK funded studentship. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply - Please follow the instructions on the following webpage: (

Notes on completing the application form - Course start date: 01 October 2018.

Completing the 'Research section' - In the 'Research Title' textbox, if you are only applying for consideration by one supervisor, insert their project title. If you wish your application to be considered by more than one, insert 'Cancer research'. If you are applying for consideration by more than one supervisor, in the 'Research Summary' textbox, please insert the project title(s) being offered by the Supervisor(s) you wish to consider your application. Also in the 'Research Supervisor' textbox please insert the initials of the Supervisor(s) you wish to consider your application. Please also describe your research experience in the appropriate textbox.

Completing the 'Finance' section - We know that you are applying for a Cancer Research UK Studentship. If you have not already applied for other source(s) of funding, please tick 'no'. Then please tick 'yes' to be considered for Cambridge scholarships, and you will be considered for these in addition to a Cancer Research UK Studentship. You are not eligible for AHRC funding.

Course Specific Questions - Please add a Covering Letter as the last two pages of your CV. Your Covering Letter should explain why you wish to be considered for the studentship and describe the qualities and experience you would bring to the role. You will be asked to upload your CV (under Course Specific Questions).

Please quote reference SW13457 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further information